The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs.

Details

Serval ID
serval:BIB_643A99A1DD84
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs.
Journal
Blood
Author(s)
Prandoni P., Casiglia E., Tikhonoff V., Leizorovicz A., Decousus H.
Working group(s)
Calisto Investigators
Contributor(s)
Shvalb P., Kalinin R., Kachinskiy A., Pshennikov AS., Gerasimov AA., Novikov AN., Apartsin K., Chizhova E., Zubareva N., Gusev V., Mineev D., Chumakov A., Smirnov G., Krasavin V., Chernyatina M., Belikov L., Gladchenko M., Rodionov O., Scherbakov A., Sokolenko N., Alfyerova E., Belentsov S., Matyas L., Szentesi S., Simon G., Juhasz K., Hajdu L., Varga M., Mietaschk A., Kunze S., von Bilderling P., Betzl G., Gudz I., Voloshyna M., Syerna A., Giannoukas A., Saleptsis V., Koutsias S., Lazarides M., Nikolopoulos ES., Filis K., Krievins D., Gedins M., Kisis K., Camporese G., Verlato F., Andreozzi G., Davì G., Lessiani G., Pesavento R., Minotto I., Parisi R., Ambrosio G., Prisco D., Acín Garcia F., Canibano C., Trujillo J., Hirmerova SJ., Krcova E., Stanek F., Maasalu K., Gaastra M., Jeanneret CC., Mazzolai L., Banyai M., Heidemann M.
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Publication state
Published
Issued date
2011
Volume
118
Number
17
Pages
4719-4722
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Although it has been clearly demonstrated that venous thromboembolism is associated with an increased risk of subsequent overt cancer and arterial cardiovascular events in comparison with control populations, whether this association also applies to patients with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs is unknown. In 737 consecutive patients with isolated SVT not involving the sapheno-femoral junction, we conducted a retrospective investigation to assess the rate of cancer and that of arterial cardiovascular events occurring during follow-up. The event rates were compared with those occurring in 1438 controls having comparable characteristics. Both cases and controls were followed-up for an average period of 26 ± 8 months (range, 3-45). Malignancy was diagnosed in 26 cases (3.5%) and 56 controls (3.9%), leading to a hazard ratio of 0.86 (95% confidence interval, 0.55%-1.35%). Arterial cardiovascular events occurred in 32 cases (4.3%) and 63 controls (4.4%), leading to a hazard ratio of 0.97 (95% confidence interval, 0.63%-1.50%). We conclude that the occurrence of isolated SVT in the legs does not place patients at an increased risk of malignancies or arterial cardiovascular events. Whether this conclusion also applies to patients whose thrombosis involves the sapheno-femoral junction remains to be demonstrated.
Keywords
Adult, Aged, Arteries/pathology, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/etiology, Case-Control Studies, Female, Follow-Up Studies, Humans, Incidence, Leg/blood supply, Male, Middle Aged, Neoplasms/epidemiology, Neoplasms/etiology, Risk Factors, Venous Thrombosis/complications, Venous Thrombosis/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 15:12
Last modification date
20/08/2019 14:20
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