Article: article from journal or magazin.
The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs.
Shvalb P., Kalinin R., Kachinskiy A., Pshennikov AS., Gerasimov AA., Novikov AN., Apartsin K., Chizhova E., Zubareva N., Gusev V., Mineev D., Chumakov A., Smirnov G., Krasavin V., Chernyatina M., Belikov L., Gladchenko M., Rodionov O., Scherbakov A., Sokolenko N., Alfyerova E., Belentsov S., Matyas L., Szentesi S., Simon G., Juhasz K., Hajdu L., Varga M., Mietaschk A., Kunze S., von Bilderling P., Betzl G., Gudz I., Voloshyna M., Syerna A., Giannoukas A., Saleptsis V., Koutsias S., Lazarides M., Nikolopoulos ES., Filis K., Krievins D., Gedins M., Kisis K., Camporese G., Verlato F., Andreozzi G., Davì G., Lessiani G., Pesavento R., Minotto I., Parisi R., Ambrosio G., Prisco D., Acín Garcia F., Canibano C., Trujillo J., Hirmerova SJ., Krcova E., Stanek F., Maasalu K., Gaastra M., Jeanneret CC., Mazzolai L., Banyai M., Heidemann M.
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Although it has been clearly demonstrated that venous thromboembolism is associated with an increased risk of subsequent overt cancer and arterial cardiovascular events in comparison with control populations, whether this association also applies to patients with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs is unknown. In 737 consecutive patients with isolated SVT not involving the sapheno-femoral junction, we conducted a retrospective investigation to assess the rate of cancer and that of arterial cardiovascular events occurring during follow-up. The event rates were compared with those occurring in 1438 controls having comparable characteristics. Both cases and controls were followed-up for an average period of 26 ± 8 months (range, 3-45). Malignancy was diagnosed in 26 cases (3.5%) and 56 controls (3.9%), leading to a hazard ratio of 0.86 (95% confidence interval, 0.55%-1.35%). Arterial cardiovascular events occurred in 32 cases (4.3%) and 63 controls (4.4%), leading to a hazard ratio of 0.97 (95% confidence interval, 0.63%-1.50%). We conclude that the occurrence of isolated SVT in the legs does not place patients at an increased risk of malignancies or arterial cardiovascular events. Whether this conclusion also applies to patients whose thrombosis involves the sapheno-femoral junction remains to be demonstrated.
Adult, Aged, Arteries/pathology, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/etiology, Case-Control Studies, Female, Follow-Up Studies, Humans, Incidence, Leg/blood supply, Male, Middle Aged, Neoplasms/epidemiology, Neoplasms/etiology, Risk Factors, Venous Thrombosis/complications, Venous Thrombosis/epidemiology
Web of science
Last modification date