Ventricular coupling of electrical and mechanical dyssynchronization in heart failure patients

Details

Serval ID
serval:BIB_64039DA995C5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Ventricular coupling of electrical and mechanical dyssynchronization in heart failure patients
Journal
Pacing Clin Electrophysiol
Author(s)
Toussaint  J. F., Lavergne T., Kerrou K., de Dieuleveult  B., Ponce F., Froissart M., Le Heuzey  J. Y., Guize L., Paillard M.
ISSN-L
0147-8389 (Print) 0147-8389 (Linking)
Publication state
Published
Issued date
2002
Volume
25
Number
2
Pages
178-82
Notes
Toussaint, Jean-Francois
Lavergne, Thomas
Kerrou, Khaldoun
de Dieuleveult, Barbara
Ponce, Felizardo
Froissart, Marc
Le Heuzey, Jean-Yves
Guize, Louis
Paillard, Michel
eng
Research Support, Non-U.S. Gov't
2002/03/28 10:00
Pacing Clin Electrophysiol. 2002 Feb;25(2):178-82.
Abstract
We studied the relationships of electrical and mechanical synchronization in patients with heart failure (CHF) and various degree of ventricular conduction delays. Ninety-two CHF patients (60 +/- 13 years old, LVEF < 45%), NYHA II-III-IV, and 35 age-matched control subjects were studied with angioscintigraphic phase analysis. We measured ejection fractions (LVEF, RVEF) and calculated the total activation time for the left (TtLV) and right ventricle (TtRV), and the synchronization time between right and left ventricle (TRVLV), and between LV apex and base (Tab). Patients were divided into three groups according to QRS duration: group 1 < 120 ms (n = 28), group 2 < 150 ms (n = 23), group 3 > or = 150 ms (n = 41). In group 1: LVEF = 31.1 +/- 10.9%, RVEF = 30.1 +/- 12.6%, TtLV = 204 +/- 70 ms, TtRV = 183 +/- 61 ms, TRVLV = 7 +/- 33 ms, Tab = 29 +/- 23 ms. In group 2, these were: 27.8 +/- 9.1%, 27.8 +/- 8.8%, 227 +/- 95 ms, 248 +/- 137 ms, 35 +/- 42 ms*, and 39 +/- 53 ms respectively. In group 3: LVEF = 20.5 +/- 9.5%t, RVEF = 28.4 +/- 16.1%, TtLV = 304 +/- 155 mst, TtRV = 234 +/- 106 mst, TRVLV = 64 +/- 42 mst, and Tab = 67 +/- 48 ms*, all P < 0.001 versus controls *P < 0.05 versus G1, tP < or = 0.01 versus G1. A significant relation links QRS to both inter- and intraventricular asynchrony (TRVLV: r = 0.65; TtLL: r = 0.70, Tab: r = 0.60), and to LV function (r = 0.72); while LVEF relates more closely to intraventricular asynchrony: TtLV (r = 0.52), TtLL (r = 0.67), than to interventricular asynchrony: TRVLV (r = 0.48); P < 0.01, P < or = 0.001. In CHF patients, electromechanical and contractile alterations are coupled; regional activation may be an early parameter allowing the detection of ventricular dyssynchronization.
Keywords
Bundle-Branch Block/physiopathology, Case-Control Studies, Female, Gated Blood-Pool Imaging, Heart Conduction System/*physiopathology, Heart Failure/*physiopathology/radionuclide imaging, Humans, Male, Middle Aged, Myocardial Contraction, Stroke Volume, Ventricular Dysfunction, Left/*physiopathology, Ventricular Function, Left, Ventricular Function, Right
Create date
03/03/2016 16:49
Last modification date
21/08/2019 5:35
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