Regulation of mitochondrial biogenesis.

Details

Serval ID
serval:BIB_61DB56725866
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Regulation of mitochondrial biogenesis.
Journal
Essays in Biochemistry
Author(s)
Jornayvaz F.R., Shulman G.I.
ISSN
1744-1358 (Electronic)
ISSN-L
0071-1365
Publication state
Published
Issued date
2010
Volume
47
Pages
69-84
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only recently been elucidated. Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer's disease. PGC-1alpha (peroxisome-proliferator-activated receptor gamma co-activator-1alpha) is a co-transcriptional regulation factor that induces mitochondrial biogenesis by activating different transcription factors, including nuclear respiratory factor 1 and nuclear respiratory factor 2, which activate mitochondrial transcription factor A. The latter drives transcription and replication of mitochondrial DNA. PGC-1alpha itself is regulated by several different key factors involved in mitochondrial biogenesis, which will be reviewed in this chapter. Of those, AMPK (AMP-activated protein kinase) is of major importance. AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. Given the potentially important role of mitochondrial dysfunction in the pathogenesis of numerous diseases and in the process of aging, understanding the molecular mechanisms regulating mitochondrial biogenesis and function may provide potentially important novel therapeutic targets.
Keywords
AMP-Activated Protein Kinases/metabolism, Biogenesis, DNA, Mitochondrial/genetics, Mitochondria/genetics, Mitochondria/metabolism, Models, Biological
Pubmed
Web of science
Create date
03/11/2015 12:34
Last modification date
20/08/2019 14:18
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