Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.

Details

Serval ID
serval:BIB_60D73A9D225F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.
Journal
Journal of Neurosurgery
Author(s)
Said N., Elias W.J., Raghavan P., Cupino A., Tustison N., Frysinger R., Patrie J., Xin W., Wintermark M.
ISSN
1933-0693 (Electronic)
ISSN-L
0022-3085
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
121
Number
4
Pages
929-935
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Object The purpose of this study was to investigate whether diffusion tensor imaging (DTI) of the corticospinal tract (CST) is a reliable surrogate for intraoperative macrostimulation through the deep brain stimulation (DBS) leads. The authors hypothesized that the distance on MRI from the DBS lead to the CST as determined by DTI would correlate with intraoperative motor thresholds from macrostimulations through the same DBS lead. Methods The authors retrospectively reviewed pre- and postoperative MRI studies and intraoperative macrostimulation recordings in 17 patients with Parkinson disease (PD) treated by DBS stimulation. Preoperative DTI tractography of the CST was coregistered with postoperative MRI studies showing the position of the DBS leads. The shortest distance and the angle from each contact of each DBS lead to the CST was automatically calculated using software-based analysis. The distance measurements calculated for each contact were evaluated with respect to the intraoperative voltage thresholds that elicited a motor response at each contact. Results There was a nonsignificant trend for voltage thresholds to increase when the distances between the DBS leads and the CST increased. There was a significant correlation between the angle and the voltage, but the correlation was weak (coefficient of correlation [R] = 0.36). Conclusions Caution needs to be exercised when using DTI tractography information to guide DBS lead placement in patients with PD. Further studies are needed to compare DTI tractography measurements with other approaches such as microelectrode recordings and conventional intraoperative MRI-guided placement of DBS leads.
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2014 19:10
Last modification date
20/08/2019 14:18
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