Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.

Details

Serval ID
serval:BIB_5F11C3DC0624
Type
Article: article from journal or magazin.
Collection
Publications
Title
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.
Journal
Nature
Author(s)
Tschopp J., Müller-Eberhard H.J., Podack E.R.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Publication state
Published
Issued date
1982
Volume
298
Number
5874
Pages
534-538
Language
english
Abstract
The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.
Keywords
Cell Membrane/metabolism, Chemical Phenomena, Chemistry, Complement Activation, Complement C9/metabolism, Lipid Bilayers/metabolism, Macromolecular Substances, Models, Biological, Protein Conformation
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 14:16
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