Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy.

Details

Serval ID
serval:BIB_5EB3F1D2E9C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy.
Journal
International journal of cancer. Journal international du cancer
Author(s)
Zaman K., Driscoll R., Hahn D., Werffeli P., Goodman S.L., Bauer J., Leyvraz S., Lejeune F., Stupp R., Rüegg C.
ISSN
0020-7136
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
118
Number
3
Pages
755-64
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Anti-angiogenic therapies are currently in cancer clinical trials, but to date there are no established tests for evaluating the angiogenic status of a patient. We measured 11 circulating angiogenesis-associated molecules in cancer patients before and after local treatment. The purpose of our study was to screen for possible relationships among the different molecules and between individual molecules and tumor burden. We measured VEGF-A, PlGF, SCF, MMP-9, EDB+ -fibronectin, sVEGFR-2, sVEGFR-1, salphaVbeta3, sTie-2, IL-8 and CRP in the blood of 22 healthy volunteers, 17 early breast, 17 early colorectal, and 8 advanced sarcoma/melanoma cancer patients. Breast cancer patients had elevated levels of VEGF-A and sTie-2, colorectal cancer patients of VEGF-A, MMP-9, sTie-2, IL-8 and CRP, and melanoma/sarcoma patients of sVEGFR-1. salphaVbeta3 was decreased in colorectal cancer patients. A correlation between VEGF-A and MMP-9 was found. After tumor removal, MMP-9 and salphaVbeta3 significantly decreased in breast and CRP in colorectal cancer, whereas sVEGFR-1 increased in colorectal cancer patients. In sarcoma/melanoma patients treated regionally with TNF and chemotherapy we observed a rise in VEGF-A, SCF, VEGFR-2, MMP-9, Tie-2 and CRP, a correlation between CRP and IL-8, and a decreased in sVEGFR-1 levels. In conclusion, among all factors measured, only VEGF-A and MMP-9 consistently correlated to each other, elevated CRP levels were associated with tumor burden, whereas sVEGF-R1 increased after tumor removal in colorectal cancer. Treatment with chemotherapy and TNF induced changes consistent with an angiogenic switch. These results warrant a prospective study to compare the effect of surgical tumor removal vs. chemotherapy on some of these markers and to evaluate their prognostic/predictive value.
Keywords
Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Colorectal Neoplasms, Female, Humans, Male, Matrix Metalloproteinase 9, Melanoma, Neoplasm Invasiveness, Neoplasms, Ductal, Lobular, and Medullary, Neovascularization, Pathologic, Sarcoma, Skin Neoplasms, Tumor Markers, Biological, Tumor Necrosis Factor-alpha, Vascular Endothelial Growth Factor A
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 8:36
Last modification date
24/02/2024 7:34
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