The genetic cohorts: facing the new challenges in infectious diseases. The HIV model

Details

Serval ID
serval:BIB_5E3928C1DC56
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The genetic cohorts: facing the new challenges in infectious diseases. The HIV model
Journal
Enfermedades Infecciosas y Microbiologia Clinica
Author(s)
Telenti  A.
ISSN
0213-005X (Print)
Publication state
Published
Issued date
07/2004
Volume
22
Number
6
Pages
337-41
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun-Jul
Abstract
All physicians are confronted with the diversity of susceptibility to infectious diseases or response to medication among patients. Much work has been done to characterize the virulence factors of pathogens, while less is known about the host (human) factor. Two unrelated people share about 99.9% of their DNA sequences, while the remaining 0.1% contains the genetic variants that influence how they differ in their risk of disease or response to drugs. The completion of the Human Genome Project gives a new start to developing the field of host genetic susceptibility. This review highlights ethical and practical issues on developing genetic cohorts by using the model of the Swiss HIV Cohort Study.
Keywords
Anti-HIV Agents/adverse effects/pharmacokinetics Biological Specimen Banks/organization & administration Cohort Studies Confidentiality Databases, Genetic Delivery of Health Care, Integrated/organization & administration *Genetic Predisposition to Disease Genetics, Medical/organization & administration/*trends Genome, Human HIV Infections/*epidemiology/genetics Humans Informed Consent Metabolic Detoxication, Drug/genetics Models, Genetic Pharmacogenetics Polymorphism, Genetic Risk Switzerland *Variation (Genetics)
Pubmed
Web of science
Create date
25/01/2008 14:46
Last modification date
20/08/2019 14:16
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