In vivo phosphorus 31 magnetic resonance spectroscopy of human uveal melanomas and other intraocular tumors
Details
Serval ID
serval:BIB_5B46BA322FDA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vivo phosphorus 31 magnetic resonance spectroscopy of human uveal melanomas and other intraocular tumors
Journal
American Journal of Ophthalmology
ISSN
0002-9394 (Print)
Publication state
Published
Issued date
03/1991
Volume
111
Number
3
Pages
276-88
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Abstract
We studied the feasibility of using the surface coil probe technique for the noninvasive in vivo study of ocular tumors by phosphorus 31 magnetic resonance spectroscopy. The characteristic organophosphate metabolites of suspected uveal melanomas before proton beam irradiation were determined qualitatively by phosphorus 31 magnetic resonance spectroscopy in vivo using a three-turn surface coil. Spectra of choroidal hemangioma, osteoma, and metastasis were also obtained in vivo and compared with those of uveal melanomas. Analysis of spectra performed at 1.5 T showed significant peaks of phosphomonoesters, inorganic phosphate, phosphodiesters, phosphocreatine, and adenosine 5'-triphosphates. The unusually high concentration of phosphodiesters may be considered as a marker for uveal melanomas and other choroidal tumors. By analyzing the ratio of phosphocreatine to phosphodiesters spectral area values, we interpreted qualitatively spectra of intraocular tumors to differentiate malignant tumors from benign lesions. Nevertheless, the main limitation of interpreting the spectra was their contamination by signals from surrounding tissues.
Keywords
Adult
Aged
Eye/metabolism
Eye Neoplasms/*metabolism
Female
Humans
*Magnetic Resonance Imaging
Male
Melanoma/*metabolism/secondary
Middle Aged
Organophosphorus Compounds/metabolism
Phosphorus Isotopes
Tumor Markers, Biological/metabolism
Uveal Neoplasms/*metabolism
Pubmed
Web of science
Create date
28/01/2008 14:10
Last modification date
20/08/2019 15:14