Probable metabolic interaction between methadone and fluvoxamine in addict patients.
Details
Serval ID
serval:BIB_5A88CEFC3C63
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Probable metabolic interaction between methadone and fluvoxamine in addict patients.
Journal
Therapeutic Drug Monitoring
ISSN
0163-4356 (Print)
ISSN-L
0163-4356
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
16
Number
1
Pages
42-45
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
We report five cases where fluvoxamine (FLVX) was added to maintenance treatment with methadone (MTD) in addict patients with affective disorders. In view of the implication of FLVX in several metabolic drug interactions, MTD plasma levels were measured before and after treatment with FLVX. A slight increase (approximately 20% of the MTD plasma level/dose ratio) occurred in two cases. In the remaining three patients, the interaction was more pronounced (40-100% increase of the MTD plasma level/dose ratio), with clinical manifestations of opiate withdrawal after stopping FLVX therapy in one case. Caution is needed when starting or stopping treatment with FLVX in patients receiving maintenance treatment with methadone.
Keywords
Adult, Depressive Disorder/drug therapy, Depressive Disorder/psychology, Drug Interactions, Female, Fluvoxamine/adverse effects, Fluvoxamine/pharmacokinetics, Humans, Male, Methadone/adverse effects, Methadone/pharmacokinetics, Opioid-Related Disorders/drug therapy, Opioid-Related Disorders/metabolism
Pubmed
Web of science
Create date
01/03/2013 11:22
Last modification date
20/08/2019 15:13
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