Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora.

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Version: Final published version
Serval ID
serval:BIB_5A0007B1F2C6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora.
Journal
BMC cardiovascular disorders
Author(s)
Creber C., Cooper R.S., Plange-Rhule J., Bovet P., Lambert E.V., Forrester T.E., Schoeller D., Riesen W., Korte W., Cao G., Luke A., Dugas L.R.
ISSN
1471-2261 (Electronic)
ISSN-L
1471-2261
Publication state
Published
Issued date
10/01/2018
Peer-reviewed
Oui
Volume
18
Number
1
Pages
4
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. This observation has received little attention and there have been no attempts to provide a causal explanation.
At baseline in an international comparative study on obesity, 289 participants aged 25-44 were recruited from communities in the US, the Seychelles, Ghana and South Africa and had REE measured with indirect calorimetry. All participants were thought to be free of major illness.
In multivariate regression models, both systolic and diastolic blood pressure were positively associated with REE (p < 0.01), while body mass index and fat mass were negatively correlated with systolic blood pressure (p < 0.01, and p < 0.05 respectively), but not diastolic blood pressure.
These data confirm previous reports and suggest that a common physiologic abnormality links REE and blood pressure. Elevated catecholamines, a putative metabolic characteristic of obesity, is a possible candidate to explain this association. The direct role of excess adipose tissue is open to question.
Keywords
Adiposity/ethnology, Adult, African Continental Ancestry Group, Basal Metabolism, Blood Pressure, Body Mass Index, Chi-Square Distribution, Female, Ghana/epidemiology, Humans, Hypertension/ethnology, Hypertension/metabolism, Hypertension/physiopathology, Linear Models, Male, Multivariate Analysis, Obesity/ethnology, Obesity/metabolism, Obesity/physiopathology, Risk Factors, Seychelles/epidemiology, South Africa/epidemiology, United States/epidemiology, Blood pressure, Hypertension, Obesity, Resting energy expenditure
Pubmed
Web of science
Open Access
Yes
Create date
27/01/2018 10:14
Last modification date
20/08/2019 14:13
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