Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts.

Details

Serval ID
serval:BIB_5724988BF84A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts.
Journal
Genome Research
Author(s)
Borel C., Deutsch S., Letourneau A., Migliavacca E., Montgomery S.B., Dimas A.S., Vejnar C.E., Attar H., Gagnebin M., Gehrig C., Falconnet E., Dupré Y., Dermitzakis E.T., Antonarakis S.E.
ISSN
1549-5469[electronic], 1088-9051[linking]
Publication state
Published
Issued date
2011
Volume
21
Number
1
Pages
68-73
Language
english
Abstract
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variation of the miRNA expression levels is likely to influence the expression of miRNA target genes and may therefore contribute to phenotypic differences in humans, including susceptibility to common disorders. The extent to which miRNA levels are genetically controlled is largely unknown. In this report, we assayed the expression levels of miRNAs in primary fibroblasts from 180 European newborns of the GenCord project and performed association analysis to identify eQTLs (expression quantitative traits loci). We detected robust expression for 121 miRNAs out of 365 interrogated. We have identified significant cis- (10%) and trans- (11%) eQTLs. Furthermore, we detected one genomic locus (rs1522653) that influences the expression levels of five miRNAs, thus unraveling a novel mechanism for coregulation of miRNA expression.
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2010 10:41
Last modification date
20/08/2019 14:11
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