Exercise induced asthma and endogenous opioids

Details

Serval ID
serval:BIB_566CDA8C1E3E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exercise induced asthma and endogenous opioids
Journal
Thorax
Author(s)
Gaillard  R. C., Bachman  M., Rochat  T., Egger  D., de Haller  R., Junod  A. F.
ISSN
0040-6376 (Print)
Publication state
Published
Issued date
05/1986
Volume
41
Number
5
Pages
350-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Concentrations of endogenous opioid peptides in the plasma are increased during exercise and these substances have been implicated in the pathogenesis of asthma induced by chloropropramide and alcohol in diabetic patients. This work was undertaken to determine whether exercise induced asthma might be mediated by endogenous opioids. Plasma beta endorphin, met-enkephalin, and adrenocorticotrophic hormone (ACTH) concentrations were measured in five asthmatic patients and five normal volunteers breathing cold air during exercise. In four of the patients the effect of an infusion of naloxone on FEV1 was also measured during exercise induced asthma. Exercise produced acute bronchoconstriction in all asthmatics, characterised by a fall in FEV1; whereas no change occurred in normal subjects. There was no difference in plasma met-enkephalin, beta endorphin, and ACTH concentration between the two groups. Infusion of naloxone neither prevented nor worsened exercise induced asthma. These data suggest that endogenous opioids probably do not play a part in the development of exercise induced asthma.
Keywords
Adult Asthma/*blood Asthma, Exercise-Induced/*blood Double-Blind Method Endorphins/*blood Enkephalin, Methionine/*blood Female Humans Male Naloxone/pharmacology Random Allocation beta-Endorphin
Pubmed
Web of science
Create date
15/02/2008 16:58
Last modification date
20/08/2019 14:10
Usage data