Changes in patterns of practice for prostate cancer radiotherapy in Italy 1995-2003. A survey of the Prostate Cancer Study Group of the Italian Radiation Oncology Society.

Details

Serval ID
serval:BIB_5490ED9CF7C8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Changes in patterns of practice for prostate cancer radiotherapy in Italy 1995-2003. A survey of the Prostate Cancer Study Group of the Italian Radiation Oncology Society.
Journal
Tumori
Author(s)
Pegurri L., Buglione M., Girelli G., Guarnieri A., Meattini I., Ricardi U., Mangoni M., Gabriele P., Bellavita R., Krengli M., Bonetta A., Cagna E., Bunkheila F., Borghesi S., Signor M., Di Marco A., Bertoni F., Stefanacci M., Gatta R., De Bari B., Magrini S.M.
ISSN
2038-2529 (Electronic)
ISSN-L
0300-8916
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
100
Number
1
Pages
31-37
Language
english
Notes
Publication types: Journal Article
Abstract
Aims and background. In 2002, a survey including 1759 patients treated from 1980 to 1998 established a "benchmark" Italian data source for prostate cancer radiotherapy. This report updates the previous one. Methods. Data on clinical management and outcomes of 3001 patients treated in 15 centers from 1999 through 2003 were analyzed and compared with those of the previous survey. Results. Significant differences in clinical management (-10% had abdominal ma-gnetic resonance imaging; +26% received ≥70 Gy, +48% conformal radiotherapy, -20% pelvic radiotherapy) and in G3-4 toxicity rates (-3.8%) were recorded. Actuarial 5-year overall, disease-specific, clinical relapse-free, and biochemical relapse-free survival rates were 88%, 96%, 96% and 88%, respectively. At multivariate analysis, D'Amico risk categories significantly impacted on all the outcomes; higher radiotherapy doses were significantly related with better overall survival rates, and a similar trend was evident for disease-specific and biochemical relapse-free survival; cumulative probability of 5-year late G1-4 toxicity was 24.8% and was significantly related to higher radiotherapy doses (P <0.001). Conclusions. The changing patterns of practice described seem related to an improvement in efficacy and safety of radiotherapy for prostate cancer. However, the impact of the new radiotherapy techniques should be prospectively evaluated.
Pubmed
Web of science
Create date
01/05/2014 18:03
Last modification date
20/08/2019 14:09
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