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Vasopressin dilates the rat carotid artery by stimulating V1 receptors.
Journal of Cardiovascular Pharmacology
Date de publication
The acute effects of various vasopressor agents on the diameter of the common carotid artery were studied in halothane-anesthetized normotensive rats. The animals were infused intravenously for 60 min with equipressor doses of angiotensin II (10 ng/min), the alpha1-stimulant methoxamine (5 microg/min), lysine vasopressin (5 mU/min), or vehicle. The arterial diameter was measured by using a high-resolution ultrasonic echo-tracking device. The three vasoconstrictors increased the carotid artery diameter, but this effect was significantly more pronounced with lysine vasopressin. Even a nonpressor dose of lysine vasopressin (1 mU/min) caused a significant increase in the arterial diameter. The lysine vasopressin-induced vasodilatation could be prevented by the administration of d(CH2)5Tyr(Me)AVP (10 microg, i.v.), a selective V1-vasopressinergic receptor antagonist. These data therefore suggest that a short-term increase in blood pressure induces in rats a distention of the carotid artery. The increase in arterial diameter seems to involve an active mechanism with lysine vasopressin caused by the stimulation of V1-vasopressinergic receptors.
Angiotensin II, Animals, Arginine Vasopressin, Blood Pressure, Carotid Arteries, Heart Rate, Hormone Antagonists, Infusions, Intravenous, Lysine Vasopressin, Male, Methoxamine, Rats, Rats, Wistar, Receptors, Vasopressin, Vasoconstriction, Vasoconstrictor Agents, Vasodilation
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