Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients.

Détails

ID Serval
serval:BIB_5214
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients.
Périodique
Journal of Clinical Oncology
Collaborateur(s)
International Breast Cancer Study Group
ISSN
0732-183X (Print)
ISSN-L
0732-183X
Statut éditorial
Publié
Date de publication
1996
Volume
14
Numéro
6
Pages
1885-1894
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
PURPOSE: The optimal duration and timing of adjuvant chemotherapy for breast cancer patients remain uncertain and were prospectively studied.
PATIENTS AND METHODS: We randomly assigned 1,554 premenopausal breast cancer patients with node-positive disease in a 2 x 2 factorial design to receive the following: (A) cyclophosphamide, methotrexate, and fluorouracil for 6 consecutive courses on months 1 to 6 (CMF x 6); (B) CMFx6 plus three single courses of reintroduction CMF given on months 9, 12, and 15; (C) CMF for three consecutive courses on months 1 to 3 (CMFx3); or (D) CMFx3 plus three single courses of reintroduction CMF given on months 6, 9, and 12. Accrual was between July 1986 and April 1993. A total of 1,475 patients (95%) were eligible and assessable. The median follow-up duration was 60 months.
RESULTS: Patients who received CMFx3 without reintroduction had a 5-year disease-free survival (DFS) rate of 53% compared with 58% for the other three treatment groups (hazards ratio [HR], 1.20; 95% confidence interval [CI], 1.00 to 1.45; P = .04). The increased risk of relapse with CMFx3 was more marked for women aged less than 40 years (308 patients; HR, 1.32; 95% CI, 0.94 to 1.84; P = .11) and for patients with estrogen receptor (ER)-negative tumors (455 patients; HR, 1.45; 95% CI, 1.06 to 2.00; P = .02). Reintroduction chemotherapy provided additional benefit (HR, 0.86; 95% CI, 0.73 to 1.01; p = .07), especially for women > or = 40 years of age (1,167 patients; HR, 0.82; 95% CI, 0.68 to 0.99; P = .04).
CONCLUSION: Three courses of adjuvant CMF chemotherapy are not sufficient compared with longer duration CMF chemotherapy, especially in younger women and in patients with ER-negative primary tumors. Reintroduction chemotherapy showed some evidence of additional benefit, but remains investigational.
Mots-clé
Adult, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Breast Neoplasms/drug therapy, Breast Neoplasms/mortality, Chemotherapy, Adjuvant, Combined Modality Therapy, Cyclophosphamide/administration & dosage, Cyclophosphamide/adverse effects, Disease-Free Survival, Drug Administration Schedule, Female, Fluorouracil/administration & dosage, Fluorouracil/adverse effects, Humans, Lymphatic Metastasis, Methotrexate/administration & dosage, Methotrexate/adverse effects, Premenopause, Treatment Failure
Pubmed
Création de la notice
19/11/2007 13:41
Dernière modification de la notice
03/03/2018 17:12
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