Oncogenes et antioncogenes: la genetique des cancers. [Oncogenes and anti-oncogenes: the genetics of cancer]

Détails

ID Serval
serval:BIB_51A69B6B0FF7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Oncogenes et antioncogenes: la genetique des cancers. [Oncogenes and anti-oncogenes: the genetics of cancer]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Schorderet  D. F., Munier  F. L.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
08/1996
Volume
85
Numéro
35
Pages
1019-22
Notes
English Abstract
Journal Article --- Old month value: Aug 27
Résumé
Oncogenes and anti-oncogenes form two families of genes. If abnormal both may induce malignancies. They are distinguished, however, by two components. Oncogenes play a certain role in a given period of development (mainly during organogenesis). As soon as function has been completed they are inactivated. Aberrant reactivation even of one allele may induce tumors in different tissues independent of age. Anti-oncogenes on the other hand protect the organism, functioning mainly at the level of cell cycle regulation. Because one allele is sufficient for sustaining of adequate function both alleles of the anti-oncogene must be destroyed before tumor development is possible. Such a tumor will be tissue- and age-specific.
Mots-clé
Embryonic and Fetal Development/genetics Genes, Retinoblastoma Genes, Tumor Suppressor/*physiology Humans Mutation Neoplasms/*genetics Oncogenes/*physiology Philadelphia Chromosome Translocation, Genetic
Pubmed
Création de la notice
28/01/2008 13:58
Dernière modification de la notice
03/03/2018 17:11
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