What is the value of hypothermia in acute neurologic diseases and status epilepticus?

Détails

ID Serval
serval:BIB_515C8A0CF9AB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
What is the value of hypothermia in acute neurologic diseases and status epilepticus?
Périodique
Epilepsia
Auteur(s)
Rossetti A.O.
ISSN
1528-1167 (Electronic)
ISSN-L
0013-9580
Statut éditorial
Publié
Date de publication
2011
Volume
52
Numéro
Suppl. 8
Pages
64-66
Langue
anglais
Résumé
Patients with status epilepticus that proves refractory to anesthetic agents represent a daunting challenge for treating clinicians. Animal data support the neuroprotective action of brain hypothermia, and its efficacy in status epilepticus models. This approach, targeting a core temperature of about 33°C for at least 24 hours together with pharmacological sedation, has been described in adults and children. However, although relatively safe if concomitant barbiturates are avoided, it seems that mild hypothermia rarely allows a sustained control of ongoing status epilepticus, since seizures tend to recur in normothermia. Conversely, mild hypothermia has a high-evidence level and is increasingly used in postanoxic encephalopathy, both in newborns and adults. Due to the paucity of available clinical data, prospective studies are needed to assess the value of hypothermia in status epilepticus.
Mots-clé
Animals, Humans, Hypothermia, Induced/methods, Nervous System Diseases/therapy, Status Epilepticus/therapy, Time Factors
Pubmed
Web of science
Création de la notice
17/11/2011 10:47
Dernière modification de la notice
03/03/2018 17:11
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