Influence of age and body mass index on gamma-glutamyltransferase activity: a 15-year follow-up evaluation in a community sample

Details

Serval ID
serval:BIB_50FF9E6B86E7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Influence of age and body mass index on gamma-glutamyltransferase activity: a 15-year follow-up evaluation in a community sample
Journal
Alcoholism, Clinical and Experimental Research
Author(s)
Daeppen  J. B., Smith  T. L., Schuckit  M. A.
ISSN
0145-6008 (Print)
Publication state
Published
Issued date
06/1998
Volume
22
Number
4
Pages
941-4
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun
Abstract
Most clinicians and researchers view serum gamma-glutamyltransferase (GGT) activity as a measure that can be interpreted equally in patients regardless of their demography. The present study evaluates the concurrent influence of age and body mass index (BMI) on GGT in a sample of 133 high functioning young men, with detailed assessment of the pattern of alcohol use at ages 20 [time 1 (T1)], 30 [time 2 (T2)], and 35 [time 3 (T3)]. GGT increased between T1 and T2 (15.4 +/- 9.65 units/liter vs. 20.1 +/- 12.07 units/liter, t = 4.17, p < 0.001), and between T2 and T3 (20.1 +/- 12.07 units/liter vs. 27.3 +/- 24.69 units/liter, t = 4.11, p < 0.001). Controlling for drinking quantity and frequency did not change the finding. The relationship between GGT and BMI was estimated after splitting the sample into normal (BMI < or = 25 kg/m2) and overweight (BMI > 25 kg/m2) subjects. The correlation between GGT and BMI in normal weight men at T1 was r = 0.15, p = 0.09, at T2 r = 0.00, p = 0.96, and at T3 r = 0.09, p = 0.09. In overweight subjects, correlation at T1 was r = 0.40, p = 0.20, at T2 r = 0.36, p < 0.05, and at T3 r = 0.44, p < 0.001. Controlling for the effect of alcohol consumption and/or age did not alter these conclusions. Testing for the interaction of age, BMI, and alcohol consumption did not yield relevant results. We concluded that GGT is positively related to age in the 20s to late 30s and to BMI in overweight subjects; both relationships of age and BMI were independent of alcohol consumption. The interpretation of GGT should take age and BMI into account when suspecting subclinical alcohol problems in young men.
Keywords
Adult Age Factors Alcoholism/*diagnosis/enzymology/genetics *Body Mass Index Child of Impaired Parents Follow-Up Studies Humans Male Reference Values Risk Factors Sensitivity and Specificity gamma-Glutamyltransferase/*blood
Pubmed
Web of science
Create date
25/01/2008 17:13
Last modification date
20/08/2019 14:06
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