Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.

Details

Ressource 1Download: BIB_50E653B7C67B.P001.pdf (2752.15 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_50E653B7C67B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.
Journal
Journal of Experimental Medicine
Author(s)
Jiang W., Wang X., Zeng B., Liu L., Tardivel A., Wei H., Han J., Macdonald H.R., Tschopp J., Tian Z., Zhou R.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
2013
Volume
210
Number
11
Pages
2465-2476
Language
english
Abstract
NOD2 functions as an intracellular sensor for microbial pathogen and plays an important role in epithelial defense. The loss-of-function mutation of NOD2 is strongly associated with human Crohn's disease (CD). However, the mechanisms of how NOD2 maintains the intestinal homeostasis and regulates the susceptibility of CD are still unclear. Here we found that the numbers of intestinal intraepithelial lymphocytes (IELs) were reduced significantly in Nod2(-/-) mice and the residual IELs displayed reduced proliferation and increased apoptosis. Further study showed that NOD2 signaling maintained IELs via recognition of gut microbiota and IL-15 production. Notably, recovery of IELs by adoptive transfer could reduce the susceptibility of Nod2(-/-) mice to the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Our results demonstrate that recognition of gut microbiota by NOD2 is important to maintain the homeostasis of IELs and provide a clue that may link NOD2 variation to the impaired innate immunity and higher susceptibility in CD.
Keywords
000325997600023
Pubmed
Web of science
Open Access
Yes
Create date
14/11/2013 9:25
Last modification date
20/08/2019 14:06
Usage data