Aortic valve dysfunction and aortic dilation in adults with coarctation of the aorta.

Détails

ID Serval
serval:BIB_508BC3569746
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aortic valve dysfunction and aortic dilation in adults with coarctation of the aorta.
Périodique
Congenital Heart Disease
Auteur(s)
Clair M., Fernandes S.M., Khairy P., Graham D.A., Krieger E.V., Opotowsky A.R., Singh M.N., Colan S.D., Meijboom E.J., Landzberg M.J.
ISSN
1747-0803 (Electronic)
ISSN-L
1747-079X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
235-243
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
OBJECTIVES: To determine the prevalence of aortic valve dysfunction, aortic dilation, and aortic valve and ascending aortic intervention in adults with coarctation of the aorta (CoA).
BACKGROUND: Aortic valve dysfunction and aortic dilation are rare among children and adolescents with CoA. With longer follow-up, adults may be more likely to have progressive disease.
METHODS: We retrospectively reviewed all adults with CoA, repaired or unrepaired, seen at our center between 2004 and 2010.
RESULTS: Two hundred sixteen adults (56.0% male) with CoA were identified. Median age at last evaluation was 28.3 (range 18.0 to 75.3) years. Bicuspid aortic valve (BAV) was present in 65.7%. At last follow-up, 3.2% had moderate or severe aortic stenosis, and 3.7% had moderate or severe aortic regurgitation. Dilation of the aortic root or ascending aorta was present in 28.0% and 41.6% of patients, respectively. Moderate or severe aortic root or ascending aortic dilation (z-score > 4) was present in 8.2% and 13.7%, respectively. Patients with BAV were more likely to have moderate or severe ascending aortic dilation compared with those without BAV (19.5% vs. 0%; P < 0.001). Age was associated with ascending aortic dilation (P = 0.04). At most recent follow-up, 5.6% had undergone aortic valve intervention, and 3.2% had aortic root or ascending aortic replacement.
CONCLUSION: In adults with CoA, significant aortic valve dysfunction and interventions during early adulthood were uncommon. However, aortic dilation was prevalent, especially of the ascending aorta, in patients with BAV.
Pubmed
Web of science
Création de la notice
18/07/2014 19:07
Dernière modification de la notice
03/03/2018 17:09
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