A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.

Details

Serval ID
serval:BIB_4FA43AB97BFA
Type
Article: article from journal or magazin.
Collection
Publications
Title
A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.
Journal
Molecular Cell
Author(s)
Cabodi S., Calautti E., Talora C., Kuroki T., Stein P.L., Dotto G.P.
ISSN
1097-2765 (Print)
ISSN-L
1097-2765
Publication state
Published
Issued date
2000
Volume
6
Number
5
Pages
1121-1129
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Growth control of epithelial cells differs substantially from other cell types. Activation of Fyn, a Src kinase family member, is required for normal keratinocyte differentiation. We report that increased Fyn activity by itself suppresses growth of keratinocytes, but not dermal fibroblasts, through downmodulation of EGF receptor (EGFR) signaling. Protein kinase C-eta has also been implicated in keratinocyte growth/differentiation control. We show that growth suppression of keratinocytes by PKC-eta depends mostly on Fyn. PKC-eta activity is both necessary and sufficient for Fyn activation, PKC-eta and Fyn are found in association, and recombinant PKC-eta directly activates Fyn. Thus, our findings reveal a direct cross talk between PKC-eta and Fyn, which presides over the decision between keratinocyte (epithelial) cell growth and differentiation.
Keywords
Animals, Cell Differentiation, Cell Division, Cells, Cultured, Cyclin-Dependent Kinases/metabolism, Cyclins/antagonists & inhibitors, Cyclins/metabolism, Enzyme Activation, Fibroblasts/cytology, Fibroblasts/enzymology, Gene Deletion, Isoenzymes/antagonists & inhibitors, Isoenzymes/genetics, Keratinocytes/cytology, Keratinocytes/enzymology, Mice, Mitosis, Organ Specificity, Protein Binding, Protein Kinase C/antagonists & inhibitors, Protein Kinase C/genetics, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-fyn, Receptor, Epidermal Growth Factor/antagonists & inhibitors, Receptor, Epidermal Growth Factor/metabolism, Recombinant Proteins/antagonists & inhibitors, Recombinant Proteins/metabolism, Signal Transduction, Skin, Transglutaminases/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:58
Last modification date
20/08/2019 14:05
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