Conditions d'intubation: importance de la fréquence de répétition du train de quatre [Intubation conditions: importance of the rate of repetition of the train-of-four]

Details

Serval ID
serval:BIB_4E1C4C6FD054
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Conditions d'intubation: importance de la fréquence de répétition du train de quatre [Intubation conditions: importance of the rate of repetition of the train-of-four]
Journal
Annales Françaises d'Anesthésie et de Réanimation
Author(s)
de Quattro A., Gardaz J.P., Bissonnette B.
ISSN
0750-7658
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
15
Number
7
Pages
1032-1036
Language
french
Notes
Publication types: Clinical Trial ; Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
Abstract
OBJECTIVES: To assess that neuromuscular relaxation onset of the adductor pollicis (AP) is related to neuromuscular stimulation rate. To assess that train-of-four (TOF) at 0.05 Hz is a more accurate indicator of optimal tracheal intubation time and conditions, than TOF at 0.08 Hz. STUDY DESIGN: Prospective, comparative, randomized double-blind study. PATIENTS: Forty adults, physical class ASA 1 or 2, undergoing general anaesthesia with tracheal intubation were allocated to two groups (n = 20) according to the sequence of stimulation of the AP: either TOF at 0.05 Hz (test group) or TOF at 0.08 Hz (control group). METHODS: Induction of anaesthesia was achieved with thiopentone, fentanyl and vecuronium (0.1 mg.kg-1). Neuromuscular monitoring was obtained with force displacement transducers attached to each AP. Tracheal intubation was performed once AP muscular response obtained with TOF at 0.05 Hz for test group and TOF at 0.08 Hz for control group was abolished. Results are expressed as mean +/- SEM. Fisher exact test was used for intubation conditions comparison. Curarization time between groups was compared with unpaired Student's t test (P < 0.05 accepted). RESULTS: TOF with 0.05 Hz stimulation significantly increased curarization time: 217 +/- 7 versus 162 +/- 6 s (P < 0.001). Intubation conditions were excellent in 95% and good in 5% of patients in the study group, compared to 15 and 40% in the control group, respectively (P < 0.01) in 45% of the control group patients coughing at intubation occurred. CONCLUSION: Low stimulation rate (TOF at 0.05 Hz) of AP is a reliable technique to determine the appropriate intubation time for patients paralyzed with vecuronium.
Keywords
Humans, Intubation, Intratracheal, Monitoring, Intraoperative, Neuromuscular Nondepolarizing Agents/pharmacology, Transcutaneous Electric Nerve Stimulation, Vecuronium Bromide/pharmacology
Pubmed
Web of science
Create date
28/01/2008 10:48
Last modification date
20/08/2019 14:03
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