Negative segregation of Mtv loci in H-2E+ mice selected for high antibody response

Details

Serval ID
serval:BIB_4DCDCDC9607C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Negative segregation of Mtv loci in H-2E+ mice selected for high antibody response
Journal
Immunogenetics
Author(s)
Roger  T., Boudaly  S., Seman  M.
ISSN
0093-7711 (Print)
Publication state
Published
Issued date
1994
Volume
40
Number
2
Pages
123-8
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Endogenous mouse mammary tumor proviruses (Mtvs) encode superantigens (Sags), which can delete T lymphocytes expressing particular Tcrb-V genes when associated with the H-2E molecule. In the present work, distribution of Mtvs was investigated in six independent pairs of mouse lines genetically selected for high (H) or low (L) Ab production to specific T-cell-dependent Ags. These experiments were performed to evaluate the role of Mtv-encoded Sags in the determination of H and L phenotypes. No systematic difference is observed in Mtv segregation between H-2E- H and L mouse lines. However, a clear differential segregation of Mtv loci is observed between H-2E+ H and L mice from three independent selections. The number of endogenous Mtvs in L lines is close to that found in laboratory mice. In contrast, Mtv loci-encoding Sags are almost absent in H animals. Although Sags profoundly affect the available Tcrb-V repertoire in H-2E+ L mice, it seems unlikely that Mtvs account for the L phenotype which can be achieved independently of Mtv segregation in H-2E- lines. More importantly, the results suggest that negative segregation of Mtv-encoding Sags contribute to determine the super-responder phenotype of H lines.
Keywords
Animals Antibody Formation/*genetics Gene Rearrangement, beta-Chain T-Cell Antigen Receptor H-2 Antigens/*genetics Immune System Mammary Tumor Virus, Mouse/*genetics/immunology Mice Mice, Inbred Strains Proviruses/*genetics/immunology Receptors, Antigen, T-Cell, alpha-beta/biosynthesis Selection (Genetics) Superantigens/*genetics/immunology
Pubmed
Web of science
Create date
25/01/2008 13:35
Last modification date
20/08/2019 14:03
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