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Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences.
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Efficiency of lymphoma induction by herpesvirus saimiri (HVS) isolates correlates with the genetically defined viral subgroups A, B, and C. To compare subgroup-specific effects, highly susceptible tamarins were infected with HVS strain A-11, B-SMHI, or C-488. All animals developed T-cell lymphomas indistinguishable with respect to clinical, pathological, and virological parameters. Ex vivo T-cell lines were established readily from the HVS C-488 animal, less efficiently in the presence of HVS A-11, and from only a single HVS B-SMHI sample. These cultivated cells revealed strain-specific biochemical characteristics. HVS A-11 strongly induced the expression of tyrosine kinase Lyn. HVS C-488 led to the activation of STAT3, which is most likely linked to the association of virus-encoded Tip with tyrosine kinase Lck. The lack of these activities in HVS B-SMHI-transformed cells may correlate with the reduced oncogenic phenotype of this virus in species other than tamarins.
Animals, Cell Line, Transformed, DNA-Binding Proteins/metabolism, Herpesviridae Infections/pathology, Herpesviridae Infections/virology, Herpesvirus 2, Saimiriine/classification, Herpesvirus 2, Saimiriine/pathogenicity, Lymphoma, T-Cell/pathology, Lymphoma, T-Cell/virology, Oncogene Proteins, Viral/genetics, Oncogene Proteins, Viral/metabolism, Phosphoproteins/metabolism, Phosphorylation, Protein-Tyrosine Kinases/metabolism, STAT3 Transcription Factor, Saguinus, T-Lymphocytes/virology, Trans-Activators/metabolism, Tumor Cells, Cultured, Tumor Virus Infections/pathology, Tumor Virus Infections/virology, Viral Proteins/metabolism
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