Meningococcal disease in a kidney transplant recipient with mannose-binding lectin deficiency.

Détails

ID Serval
serval:BIB_4D6F3DA5FEF7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Meningococcal disease in a kidney transplant recipient with mannose-binding lectin deficiency.
Périodique
Transplant Infectious Disease
Auteur(s)
Manuel O., Tarr P.E., Venetz J.P., Trendelenburg M., Meylan P.R., Pascual M.
ISSN
1398-2273
Statut éditorial
Publié
Date de publication
09/2007
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
214-218
Langue
anglais
Résumé
We describe the case of a kidney transplant recipient who developed meningococcemia, without meningeal signs, 2 months after transplantation. Plasma levels of complement components C3, C4, and CH 50 were within the normal range. However, using a method to screen for the functional activity of all 3 pathways of complement, no activation via the mannose-binding lectin (MBL) pathway could be detected (0%). A subsequent quantification of MBL pathway components revealed normal levels of MASP 2 but undetectable amounts of MBL. To our knowledge, this is the first report of meningococcal disease after organ transplantation in a patient with MBL deficiency.
Mots-clé
Adult, Complement Pathway, Mannose-Binding Lectin, Humans, Kidney Transplantation, Male, Mannose-Binding Lectin, Meningococcal Infections, Neisseria meningitidis, Postoperative Complications
Pubmed
Web of science
Création de la notice
20/01/2008 16:55
Dernière modification de la notice
20/08/2019 14:02
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