CYP3A5 and ABCB1 genes and hypertension.
Details
Serval ID
serval:BIB_4D26D0016704
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
CYP3A5 and ABCB1 genes and hypertension.
Journal
Pharmacogenomics
ISSN
1744-8042 (Electronic)
ISSN-L
1462-2416
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
10
Number
3
Pages
477-487
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Hypertension is the first single modifiable cause of disease burden worldwide. Genes encoding proteins that are involved in the metabolism (CYP3A5) and transport (ABCB1) of drugs and hormones might contribute to blood pressure control in humans. Indeed, recent data have suggested that CYP3A5 and ABCB1 gene polymorphisms are associated with blood pressure in the rat as well as in humans. Interestingly, the effects of these genes on blood pressure appear to be modified by dietary salt intake. This review summarizes what is known regarding the relationships of the ABCB1 and CYP3A5 genes with blood pressure, and discusses the potential underlying mechanisms of the association. If the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans.
Keywords
Alternative Splicing/genetics, Blood Pressure/genetics, Blood Pressure/physiology, Cytochrome P-450 CYP3A/genetics, Cytochrome P-450 CYP3A/metabolism, Female, Genetic Variation, Homeostasis, Humans, Hypertension/enzymology, Hypertension/genetics, Introns, Male, P-Glycoprotein/genetics, RNA, Messenger/genetics
Pubmed
Web of science
Create date
20/03/2009 10:01
Last modification date
20/08/2019 15:01
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