Is leptin the link between fat and bone mass?

Details

Serval ID
serval:BIB_4B78F7030F78
Type
Article: article from journal or magazin.
Collection
Publications
Title
Is leptin the link between fat and bone mass?
Journal
Journal of endocrinological investigation
Author(s)
Isaia G.C., D'Amelio P., Di Bella S., Tamone C.
ISSN
0391-4097 (Print)
ISSN-L
0391-4097
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
28
Number
10 Suppl
Pages
61-65
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Leptin is a cytokine-like hormone which is considered the link between fat and bone; it is produced by adipocytes and osteoblasts, regulates food intake via specific receptors located in the central nervous system (CNS) and bone mass through alternate pathways: one involving a direct stimulatory effect on bone formation; and another indirect effect through the CNS that suppresses bone formation. Leptin exerts a direct stimulatory effect on osteoblast differentiation and on bone growth if directly administered, while it exerts an inhibitory effect on bone formation if administered in the CNS. It is therefore unclear whether leptin should be considered an antiosteogenic factor or an anabolic agent for bone formation: in all probability, leptin has a broader role in human physiology and in particular its action has evolved in order to synchronize periods of bone growth, mineral accretion and fertility with periods of food availability, while it restricts growth and reproduction during periods of nutritional stress.
Keywords
Adipocytes/physiology, Adipose Tissue/physiology, Appetite Regulation, Bone Density, Bone and Bones/cytology, Bone and Bones/physiology, Central Nervous System/physiology, Energy Metabolism, Humans, Leptin/physiology, Osteoblasts/physiology, Osteogenesis, Reproduction
Pubmed
Create date
23/01/2020 14:41
Last modification date
24/01/2020 6:26
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