Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_4B6D9B291C6E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration.
Périodique
Frontiers in cellular neuroscience
Auteur(s)
Henstridge C.M., Tzioras M., Paolicelli R.C.
ISSN
1662-5102 (Print)
ISSN-L
1662-5102
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
13
Pages
63
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to network dysfunction associated with neurodegeneration. Excitatory and inhibitory activity can be affected by glia-mediated synapse loss, resulting in imbalanced synaptic transmission and subsequent synaptic dysfunction. Here, we review the recent literature on the contribution of glia to excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. A better understanding of the mechanisms underlying pathological synapse loss will be instrumental to design targeted therapeutic interventions, taking in account the emerging roles of microglia and astrocytes in synapse remodeling.
Mots-clé
Cellular and Molecular Neuroscience, E/I imbalance, astrocytes, microglia, neurodegeneration, synapse loss
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/03/2019 23:57
Dernière modification de la notice
18/06/2019 7:08
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