An immunohistochemical study of Ki-67 in colorectal adenoma.

Details

Serval ID
serval:BIB_4B20E367C37C
Type
Article: article from journal or magazin.
Collection
Publications
Title
An immunohistochemical study of Ki-67 in colorectal adenoma.
Journal
Medicinski Arhiv
Author(s)
Radovanovic-Dinic B., Nagorni A., Katic V., Stamenkovic I., Zlatic A.
ISSN
0350-199X[print], 0350-199X[linking]
Publication state
Published
Issued date
2009
Volume
63
Number
1
Pages
16-18
Language
english
Notes
Publication types: Journal Article
Abstract
INTRODUCTION: The expression of the human Ki-67 protein is strictly associated with cell proliferation. The cell proliferation and kinetics of normal gastrointestinal tract are well known but the cell kinetics of adenoma in gastrointestinal tract is poorly understood. The aim of this study was to provide an immunohistochemical evaluation of the expression of Ki-67 antigen in different colorectal adenomas. MATERIAL AND METHODS: In the prospective study, we analyzed 65 colorectal adenomas. RESULTS: Proliferation indexes were found to steadily increase from normal mucosa to adenoma (p < 0.05). There was also a difference in the expression of Ki-67 between adenomas smaller and larger than 10 mm (p < 0.05). The expression of Ki-67 was strongly more often in villous adenomas as opposed to the tubular adenomas (p < 0.05). Reaction for Ki-67 were strong in adenomas with high grade atypia compared to low grade adenomas (p < 0.001). CONCLUSION: The expression of Ki-67 clearly shows differences between advanced and nonadvanced adenomas. The strong reactions of Ki-67 in adenomas with severe dysplasia show a close association with colorectal carcinoma. The immunohistochemical analysis (Ki-67) may be included as a part of routine pathological evaluation with conventional prognostic factors.
Keywords
Adenoma/metabolism, Adenoma/pathology, Colorectal Neoplasms/metabolism, Colorectal Neoplasms/pathology, Humans, Immunohistochemistry, Ki-67 Antigen/metabolism
Pubmed
Create date
26/08/2010 16:37
Last modification date
20/08/2019 13:58
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