Postischemic blood flow response in hypercholesterolemic patients.

Details

Serval ID
serval:BIB_4B0421F89971
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postischemic blood flow response in hypercholesterolemic patients.
Journal
Hypertension
Author(s)
Hayoz D., Weber R., Rutschmann B., Darioli R., Burnier M., Waeber B., Brunner H.R.
ISSN
0194-911X
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
26
Number
3
Pages
497-502
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
We undertook this cross-sectional study to compare the mechanical behavior and postischemic response of the radial artery of 15 newly diagnosed hypercholesterolemic patients with those of 15 age- and sex-matched normocholesterolemic control subjects and 21 hypercholesterolemic patients treated for 2 years with an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (simvastatin, 10 to 20 mg/d). At the time of the study total cholesterol levels were at 7.9 +/- 0.2, 4.9 +/- 0.2, and 6.0 +/- 0.3 mmol/L in the three groups, respectively (mean +/- SEM, P < .001). High-resolution, noninvasive echotracking for assessment of internal arterial diameter was combined with measurements of blood flow velocity by Doppler and blood pressure by photoplethysmography. Radial cross-sectional compliance and distensibility were similar in all groups. Forearm blood flow and flow-mediated dilation were measured after a 5-minute upper arm occlusion. Flow was calculated from the vessel diameter and blood flow velocity recorded simultaneously at the same site. Flow-mediated dilation after ischemia was not significantly different among the three groups. However, forearm blood flow increase was markedly blunted (P < .01) in untreated hypercholesterolemic patients (211%) compared with the normocholesterolemic control subjects (411%) and treated patients (365%). These findings suggest that the distensibility of the radial artery, a muscular conduit vessel usually devoid of atherosclerotic lesions, and its flow-mediated dilation are preserved in hypercholesterolemic patients. In contrast, forearm resistance vessels exhibit a markedly reduced postischemic blood flow response that may be restored by prolonged lipid-lowering intervention.
Keywords
Adult, Aged, Cross-Sectional Studies, Female, Humans, Hypercholesterolemia, Ischemia, Lipids, Male, Middle Aged, Radial Artery, Regional Blood Flow
Pubmed
Web of science
Create date
28/01/2008 11:45
Last modification date
20/08/2019 13:58
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