Postischemic blood flow response in hypercholesterolemic patients.
Details
Serval ID
serval:BIB_4B0421F89971
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postischemic blood flow response in hypercholesterolemic patients.
Journal
Hypertension
ISSN
0194-911X
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
26
Number
3
Pages
497-502
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
We undertook this cross-sectional study to compare the mechanical behavior and postischemic response of the radial artery of 15 newly diagnosed hypercholesterolemic patients with those of 15 age- and sex-matched normocholesterolemic control subjects and 21 hypercholesterolemic patients treated for 2 years with an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (simvastatin, 10 to 20 mg/d). At the time of the study total cholesterol levels were at 7.9 +/- 0.2, 4.9 +/- 0.2, and 6.0 +/- 0.3 mmol/L in the three groups, respectively (mean +/- SEM, P < .001). High-resolution, noninvasive echotracking for assessment of internal arterial diameter was combined with measurements of blood flow velocity by Doppler and blood pressure by photoplethysmography. Radial cross-sectional compliance and distensibility were similar in all groups. Forearm blood flow and flow-mediated dilation were measured after a 5-minute upper arm occlusion. Flow was calculated from the vessel diameter and blood flow velocity recorded simultaneously at the same site. Flow-mediated dilation after ischemia was not significantly different among the three groups. However, forearm blood flow increase was markedly blunted (P < .01) in untreated hypercholesterolemic patients (211%) compared with the normocholesterolemic control subjects (411%) and treated patients (365%). These findings suggest that the distensibility of the radial artery, a muscular conduit vessel usually devoid of atherosclerotic lesions, and its flow-mediated dilation are preserved in hypercholesterolemic patients. In contrast, forearm resistance vessels exhibit a markedly reduced postischemic blood flow response that may be restored by prolonged lipid-lowering intervention.
Keywords
Adult, Aged, Cross-Sectional Studies, Female, Humans, Hypercholesterolemia, Ischemia, Lipids, Male, Middle Aged, Radial Artery, Regional Blood Flow
Pubmed
Web of science
Create date
28/01/2008 11:45
Last modification date
20/08/2019 13:58