Low renin essential hypertension in a child

Details

Serval ID
serval:BIB_4AFAECCF5391
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Low renin essential hypertension in a child
Journal
Helvetica Paediatrica Acta
Author(s)
Leumann  E. P., Nussberger  J., Vetter  W.
ISSN
0018-022X (Print)
Publication state
Published
Issued date
01/1976
Volume
30
Number
4-5
Pages
357-63
Notes
Case Reports
Journal Article --- Old month value: Jan
Abstract
Elevated blood pressure (160/120 mm Hg) was found in an 8 1/2-year old body and remained unchanged during the following 3 years. The only abnormal findings were undetectable plasma renin activity (PRA less 0.16 ng/ml-3 h) even after sodium restriction and upright posture and a slight tendency for hypokalemia (3.7 mEq/1, lowest value 3.3 mEq/1). Plasma aldosterone (PA) and plasma cortisol (PC) were normal. Administration of dexamethasone and spironolactone resulted in only a minimal decrease of blood pressure whereas hydrochlorothiazide was slightly more effective. The circadian rhythm of PRA, PA and PC was studied by otaining frequent blood specimens during one night. The diurnal variation of PA and PC was normal despite undetectable PRA (less than 0.16 ng/ml-3 h). Primary aldosteronism and other conditions associated with mineralocorticoid excess were excluded. The patient seems to represent an example of low renin essential hypertension. This is the second recorded case of this syndrome in childhood.
Keywords
Aldosterone/blood Child Circadian Rhythm Dexamethasone/therapeutic use Humans Hydrochlorothiazide/therapeutic use Hydrocortisone/blood Hypertension/*blood/drug therapy Male Renin/*blood Spironolactone/therapeutic use
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 13:58
Usage data