The putative neuroprotective role of neuropeptide Y in the central nervous system.

Details

Serval ID
serval:BIB_4963E5B0DB0E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The putative neuroprotective role of neuropeptide Y in the central nervous system.
Journal
Current Drug Targets. CNS and Neurological Disorders
Author(s)
Silva A.P., Xapelli S., Grouzmann E., Cavadas C.
ISSN
1871-5273
1568-007X
Publication state
Published
Issued date
08/2005
Volume
4
Number
4
Pages
331-347
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Neuropeptide Y (NPY) is one of the most abundant and widely distributed neuropeptides in the mammalian central nervous system (CNS). An overview of the distribution of the G-protein coupled NPY receptor family (Y(1), Y(2), Y(4), Y(5) receptors) in the brain is described. The coexistence of NPY with other neurotransmitters and its wide distribution in several brain areas predict the high importance of NPY as a neuromodulator. Thus, the effect of NPY on the release of several neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA), norepinephrine (NE), dopamine, somastotatin (SOM), serotonin (5-HT), nitric oxide (NO), growth hormone (GH) and corticotropin releasing factor (CRF) is reviewed. A neuroprotective role for NPY under physiological conditions and during hyperactivity such as epileptic-seizures has been suggested. We have shown previously that NPY inhibits glutamate release evoked from hippocampal nerve terminals and has a neuroprotective effect in rat organotypic hippocampal cultures exposed to an excitotoxic insult. Moreover, changes in NPY levels have been observed in different pathological conditions such as brain ischemia and neurodegenerative diseases (Huntington's, Alzheimer's and Parkinson's diseases). Taken together, these studies suggest that NPY and NPY receptors may represent pharmacological targets in different pathophysiological conditions in the CNS.
Keywords
Animals, Brain/metabolism, Cell Survival/physiology, Epilepsy/metabolism, Humans, Ischemia/metabolism, Neurodegenerative Diseases/metabolism, Neuropeptide Y/metabolism, Neuroprotective Agents/metabolism, Rats, Receptors, Neuropeptide Y/classification, Receptors, Neuropeptide Y/metabolism, Tissue Distribution
Pubmed
Create date
25/01/2008 10:55
Last modification date
20/08/2019 13:56
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