Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: analytical techniques and preliminary results.
Details
Serval ID
serval:BIB_490A5CD5F4A2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: analytical techniques and preliminary results.
Journal
Neuroradiology
ISSN
0028-3940 (Print)
ISSN-L
0028-3940
Publication state
Published
Issued date
1982
Volume
23
Number
2
Pages
63-74
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Regional cerebral blood flow and oxygen utilisation have been studied in 8 patients with brain tumours using continuous inhalation of C15O2 and 15O2 and positron emission tomography. The methods used to analyse the regional cerebral pathophysiology are presented. A relative uncoupling between oxygen consumption and blood flow was observed in all tumours as indicated by a decreased regional fractional extraction of oxygen (rOER). This suggest that a major proportion of these tumours had sufficient blood supply to meet oxygen metabolic demand. A decrease of blood flow in grey matter was found both in the affected and contralateral hemispheres of the brain. Matched reductions of flow and oxygen utilisation were observed in oedematous tissue.
Keywords
Aged, Brain/metabolism, Brain Neoplasms/metabolism, Brain Neoplasms/physiopathology, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Oxygen Consumption, Oxygen Radioisotopes/diagnostic use, Tomography, Emission-Computed
Pubmed
Web of science
Create date
09/10/2011 19:39
Last modification date
20/08/2019 14:56
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