Article: article from journal or magazin.
Positron emission tomography in familial Alzheimer disease.
Alzheimer Disease and Associated Disorders
Publication types: Journal ArticlePublication Status: ppublish
There is increasing evidence for genetic heterogeneity in Alzheimer disease. A longitudinal clinical and imaging study had been established in order to determine whether specific phenotypic profiles are present in aetiologically distinct familial Alzheimer disease (FAD) pedigrees. [18F]fluorodeoxyglucose positron emission tomography has been used in conjunction with statistical parametric mapping to determine the relative distribution of hypometabolism. A parietotemporal deficit has been observed in individuals from both amyloid precursor protein mutation and chromosome 14 linked FAD families. Preliminary data from asymptomatic individuals at risk of FAD shows similar, although a less extensive pattern of deficit.
Aged, Alzheimer Disease/genetics, Alzheimer Disease/radionuclide imaging, Amyloid beta-Protein Precursor/genetics, Blood Glucose/metabolism, Brain/physiopathology, Brain/radionuclide imaging, Chromosomes, Human, Pair 14, Deoxyglucose/analogs & derivatives, Deoxyglucose/metabolism, Energy Metabolism/genetics, Energy Metabolism/physiology, Fluorodeoxyglucose F18, Genetic Linkage/genetics, Humans, Longitudinal Studies, Phenotype, Risk Factors, Tomography, Emission-Computed
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