The Interplay between the bone and the immune system.

Details

Serval ID
serval:BIB_4867FB305C01
Type
Article: article from journal or magazin.
Collection
Publications
Title
The Interplay between the bone and the immune system.
Journal
Clinical & developmental immunology
Author(s)
Mori G., D'Amelio P., Faccio R., Brunetti G.
ISSN
1740-2530 (Electronic)
ISSN-L
1740-2522
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
2013
Pages
720504
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.
Keywords
Animals, Bone Resorption/immunology, Bone and Bones/immunology, Humans, Immune System/physiology, Osteoblasts/physiology, Osteoclasts/physiology, Osteocytes/physiology, Osteogenesis/physiology
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2020 7:59
Last modification date
15/01/2020 6:26
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