Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain glioma.

Détails

ID Serval
serval:BIB_47FE7D67DA16
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain glioma.
Périodique
AJNR. American Journal of Neuroradiology
Auteur(s)
Sadeghi N., Salmon I., Decaestecker C., Levivier M., Metens T., Wikler D., Denolin V., Rorive S., Massager N., Baleriaux D., Goldman S.
ISSN
0195-6108 (Print)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
28
Numéro
3
Pages
455-461
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: Vascularity, metabolism, and histologic grade are related in gliomas but the exact determinants of these relationships are not fully defined. We used image coregistration and stereotactic biopsies to regionally compare cerebral blood volume (CBV) and (11)C-methionine (MET) uptake measurements in brain gliomas and to assess their relationship by histopathologic examination.
MATERIALS AND METHODS: Fourteen patients with brain gliomas underwent MR imaging, including dynamic susceptibility contrast-enhanced MR and positron-emission tomography (PET) using MET acquired in identical stereotactic conditions before biopsy. MR-based CBV maps were calculated and both CBV maps and PET images were coregistered to anatomic images. Sixty-five biopsy samples were obtained on trajectories targeted toward high MET uptake area. The following histopathologic features were semiquantified in each sample: mitotic activity, endothelial proliferation, cellular pleomorphism, and tumor necrosis. CBV and MET uptake values were measured in the biopsy area and normalized to contralateral white matter. CBV ratios were compared with MET uptake ratios, and both measurements were compared with histologic features of each sample.
RESULTS: CBV ratios ranged from 0.08 to 10.24 (median = 1.73), and MET uptake ratios ranged from 0.30 to 4.91 (median = 1.67). There was a positive correlation between CBV ratios and MET uptake ratios (r = 0.65, P < .001). Both CBV and MET uptake ratios were found to be significantly related to endothelial proliferation and mitotic activity (P < .01).
CONCLUSION: Within glial tumors, there is a local relationship between CBV and MET uptake measurements. Both provide indices of focal malignant activity.
Mots-clé
Adult, Aged, Biopsy, Blood Volume, Brain Neoplasms/blood supply, Brain Neoplasms/metabolism, Carbon Radioisotopes/diagnostic use, Cerebrovascular Circulation, Endothelium/metabolism, Endothelium/pathology, Female, Glioma/blood supply, Glioma/metabolism, Humans, Magnetic Resonance Imaging, Male, Methionine/pharmacokinetics, Middle Aged, Positron-Emission Tomography, Stereotaxic Techniques
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
03/03/2018 16:51
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