Correlation of intra- and extraepidermal CD8 T cell numbers with development of psoriatic epidermal pathology
Details
Serval ID
serval:BIB_47FE33B4E874
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Correlation of intra- and extraepidermal CD8 T cell numbers with development of psoriatic epidermal pathology
Title of the conference
Annual Meeting of the Society for Investigative Dermatology
Address
Phoenix, Arizona, May 4-7, 2011
ISBN
0022-202X
Publication state
Published
Issued date
2011
Volume
131
Series
Journal of Investigative Dermatology
Pages
S100
Language
english
Notes
Publication type : Meeting Abstract
Abstract
The development of psoriatic plaques is T cell dependent. Recently, Th17 CD4 T cells have been proposed to be the main effector cells. However, development of psoriasis is critically dependent on accumulation of epidermal T cells, among the majority express CD8. Here we show that numbers of epidermal CD8 T cells correlated with development of psoriasis in human biopsies, and that blockade of CD8 T cells by depleting antibodies inhibited development of psoriasis in the AGR xenotransplantation mouse model. In human dermis, both CD4 and CD8 T cell numbers correlated significantly with epidermal pathology, indicating a role for dermal CD4 T cells in orchestrating the development of psoriasiform changes induced by epidermis-infiltrating CD8 T cells.
Keywords
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Web of science
Create date
06/05/2011 15:06
Last modification date
20/08/2019 14:54
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