Pathology of peripheral T-cell lymphomas: where do we stand?

Détails

ID Serval
serval:BIB_47F543EE058E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pathology of peripheral T-cell lymphomas: where do we stand?
Périodique
Seminars In Hematology
Auteur(s)
Gaulard P., de Leval L.
ISSN
1532-8686 (Electronic)
ISSN-L
0037-1963
Statut éditorial
Publié
Date de publication
2014
Volume
51
Numéro
1
Pages
5-16
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Peripheral T-cell lymphomas (PTCLs) are heterogeneous and uncommon malignancies characterized by a usually aggressive clinical course. The current World Health Organization (WHO) classification delineates many entities grouped according to the clinical presentation as predominantly leukemic, cutaneous, extranodal, or nodal diseases. Yet, few genetic lesions serve as entity-defining markers. Using high-throughput methods, new recurrent genetic and molecular alterations are being discovered that are expected to refine the current classification and serve as diagnostic genetic markers and targets for novel therapies. There is increasing evidence that certain cellular subsets, in particular follicular helper T cells and gamma delta T cells, represent important defining markers and/or determinants of the biology of certain entities; nevertheless, the cellular derivation of many PTCL entities remains poorly characterized and there is evidence of plasticity in terms of cellular derivation (alpha-beta, gamma-delta, natural killer [NK]) especially in several extranodal entities with a cytotoxic profile. While most clonal NK/T-cell proliferations are in general highly malignant, some more indolent forms of NK or T-cell lympho-proliferations are being identified.
Pubmed
Web of science
Création de la notice
29/01/2014 10:30
Dernière modification de la notice
03/03/2018 16:51
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