SBRT and extreme hypofractionation: A new era in prostate cancer treatments?

Détails

ID Serval
serval:BIB_47AFDD9A5823
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
SBRT and extreme hypofractionation: A new era in prostate cancer treatments?
Périodique
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
Auteur(s)
Alongi F., Fiorentino A., De Bari B.
ISSN
1507-1367 (Print)
ISSN-L
1507-1367
Statut éditorial
Publié
Date de publication
2015
Volume
20
Numéro
6
Pages
411-416
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Radiation therapy (RT) is a standard therapeutic option for prostate cancer (PC). In the last decades, several innovative technology applications have been introduced. 3-Dimensional conformal RT, volumetric/rotational intensity modulated RT associated or not with image-guided RT, are becoming largely diffused in the treatment of PC.
Considering that PC could have a low α/β ratio, similar to late-reacting normal tissues, it could also be highly responsive to fraction size. Thus, the reduction of the number of fractions and the increase of the dose/fraction seem to be reasonable choices in the treatment of this cancer. This review reported the technology evolution, the radiobiological and the clinical data about the role of extreme hypofractionated RT in the treatment approach of PC patients.
Medline search and analysis of published studies containing key words: prostate cancer, radiotherapy, stereotactic radiotherapy.
Recent technological developments, combined with an improved knowledge of the radiobiological models in favor of a high sensitivity of PC to larger fraction sizes are opening a new scenario in its treatment, reporting favorable efficacy and acceptable toxicity, despite short follow-up.
Thus, thanks to technological improvement and the recent radiobiological data, "extreme hypofractionated RT" has been strongly introduced in the last years as a potential solid treatment option for PC.

Pubmed
Création de la notice
14/02/2017 12:51
Dernière modification de la notice
03/03/2018 16:50
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