Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia

Details

Serval ID
serval:BIB_477A70DB3AF5
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia
Journal
Cancer Genetics and Cytogenetics
Author(s)
Bargetzi  M. J., Muhlematter  D., Tichelli  A., Jotterand  M., Wernli  M.
ISSN
0165-4608 (Print)
Publication state
Published
Issued date
08/1999
Volume
113
Number
1
Pages
90-2
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
A 66-year-old Caucasian woman presented with a Philadelphia chromosome positive common B-cell acute lymphoblastic leukemia and a dic(9;12) involving the der(9)t(9;22), a rearrangement so far not observed in acute lymphoblastic leukemia. The patient was treated for the acute lymphoblastic leukemia, but showed refractory disease and died 6 months after initial diagnosis. This case suggests that, in the combination of t(9;22) and dic(9;12), the known poor prognostic feature of t(9;22) in acute lymphoblastic leukemia may outweigh the favorable outcome reported in patients with dic(9;12).
Keywords
Aged Chromosome Banding *Chromosomes, Human, Pair 12 *Chromosomes, Human, Pair 9 Female Humans Karyotyping Leukemia, B-Cell, Acute/*genetics Leukemia, Lymphocytic, Acute, L2/*genetics Recurrence *Translocation, Genetic
Pubmed
Web of science
Create date
25/01/2008 14:18
Last modification date
20/08/2019 13:53
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