Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia

Détails

ID Serval
serval:BIB_477A70DB3AF5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia
Périodique
Cancer Genetics and Cytogenetics
Auteur(s)
Bargetzi  M. J., Muhlematter  D., Tichelli  A., Jotterand  M., Wernli  M.
ISSN
0165-4608 (Print)
Statut éditorial
Publié
Date de publication
08/1999
Volume
113
Numéro
1
Pages
90-2
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
A 66-year-old Caucasian woman presented with a Philadelphia chromosome positive common B-cell acute lymphoblastic leukemia and a dic(9;12) involving the der(9)t(9;22), a rearrangement so far not observed in acute lymphoblastic leukemia. The patient was treated for the acute lymphoblastic leukemia, but showed refractory disease and died 6 months after initial diagnosis. This case suggests that, in the combination of t(9;22) and dic(9;12), the known poor prognostic feature of t(9;22) in acute lymphoblastic leukemia may outweigh the favorable outcome reported in patients with dic(9;12).
Mots-clé
Aged Chromosome Banding *Chromosomes, Human, Pair 12 *Chromosomes, Human, Pair 9 Female Humans Karyotyping Leukemia, B-Cell, Acute/*genetics Leukemia, Lymphocytic, Acute, L2/*genetics Recurrence *Translocation, Genetic
Pubmed
Web of science
Création de la notice
25/01/2008 15:18
Dernière modification de la notice
03/03/2018 16:50
Données d'usage