Liver ischemia: apoptosis as a central mechanism of injury.

Détails

ID Serval
serval:BIB_474D0D8BABE3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Liver ischemia: apoptosis as a central mechanism of injury.
Périodique
Journal of Investigative Surgery
Auteur(s)
Rüdiger H.A., Graf R., Clavien P.A.
ISSN
0894-1939 (Print)
ISSN-L
0894-1939
Statut éditorial
Publié
Date de publication
2003
Volume
16
Numéro
3
Pages
149-159
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Résumé
Injuries due to cold and warm (normothermic) ischemia remain an important source of morbidity and mortality in liver surgery and transplantation. While the mechanisms of injury are complex, involving apoptotic and necrotic types of cell death, accumulating evidence points to a central role for various apoptotic pathways in mediating cell death following ischemia. A number of antiapoptotic strategies have been shown to confer a high degree of protection, including improved animal survival following long ischemic insult. The future may lie in the identification of practical and effective antiapoptotic strategies to enhance tolerance to ischemic injury.
Mots-clé
Animals, Apoptosis, Humans, Liver Diseases/pathology, Liver Diseases/surgery, Liver Transplantation, Reperfusion Injury/pathology
Pubmed
Web of science
Création de la notice
13/02/2012 9:21
Dernière modification de la notice
03/03/2018 16:49
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