Insulin and NPY pathways and the control of GnRH function and puberty onset.

Détails

ID Serval
serval:BIB_472E89C9ED31
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Insulin and NPY pathways and the control of GnRH function and puberty onset.
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Pralong F.P.
ISSN
1872-8057[electronic], 0303-7207[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
324
Numéro
1-2
Pages
82-86
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Energy balance exerts a critical influence on reproductive function. Leptin and insulin are among the metabolic factors signaling the nutritional status of an individual to the hypothalamus, and their role in the overall modulation of the activity of GnRH neurons is increasingly recognized. As such, they participate to a more generalized phenomenon: the signaling of peripheral metabolic changes to the central nervous system. The physiological importance that the interactions occurring between peripheral metabolic factors and the central nervous system bear for the control of food intake is increasingly recognized. The central mechanisms implicated are the focus of attention of very many research groups worldwide. We review here the experimental data that suggest that similar mechanisms are at play for the metabolic control of the neuroendocrine reproductive function. It is appearing that metabolic signals are integrated at the levels of first-order neurons equipped with the proper receptors, ant that these neurons send their signals towards hypothalamic GnRH neurons which constitute the integrative element of this network.
Mots-clé
Animals, Gonadotropin-Releasing Hormone/metabolism, Humans, Insulin/metabolism, Leptin/metabolism, Neuropeptide Y/metabolism, Puberty/metabolism, Sexual Maturation/physiology, Signal Transduction
Pubmed
Web of science
Création de la notice
03/11/2010 18:36
Dernière modification de la notice
03/03/2018 16:49
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