Minimization of calcineurin inhibitors to improve long-term outcomes in kidney transplantation.

Détails

ID Serval
serval:BIB_470A172EC55A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Minimization of calcineurin inhibitors to improve long-term outcomes in kidney transplantation.
Périodique
Transplant Immunology
Auteur(s)
Golshayan D., Pascual M.
ISSN
0966-3274 (Print)
ISSN-L
0966-3274
Statut éditorial
Publié
Date de publication
2008
Volume
20
Numéro
1-2
Pages
21-28
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Long-term outcomes after kidney transplantation remain suboptimal, despite the great achievements observed in recent years with the use of modern immunosuppressive drugs. Currently, the calcineurin inhibitors (CNI) cyclosporine and tacrolimus remain the cornerstones of immunosuppressive regimens in many centers worldwide, regardless of their well described side-effects, including nephrotoxicity. In this article, we review recent CNI-minimization strategies in kidney transplantation, while emphasizing on the importance of long-term follow-up and patient monitoring. Finally, accumulating data indicate that low-dose CNI-based regimens would provide an interesting balance between efficacy and toxicity.
Mots-clé
Antibodies, Monoclonal/administration & dosage, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm/administration & dosage, Antimetabolites/administration & dosage, Calcineurin/antagonists & inhibitors, Cyclosporine/administration & dosage, Graft Rejection/drug therapy, Graft Rejection/immunology, Graft Survival/drug effects, Graft Survival/immunology, Humans, Immunosuppression/methods, Immunosuppressive Agents/administration & dosage, Kidney Transplantation/mortality, Tacrolimus/administration & dosage, Treatment Outcome
Pubmed
Web of science
Création de la notice
31/08/2008 13:33
Dernière modification de la notice
20/08/2019 13:52
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