A novel experimental thrombotic myocardial infarction and primary angioplasty model in swine.

Details

Serval ID
serval:BIB_470673F927AC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A novel experimental thrombotic myocardial infarction and primary angioplasty model in swine.
Journal
EuroIntervention
Author(s)
Sideris G., Magkoutis N., Voicu S., Kang C., Bonneau M., Yannopoulos D., Bal Dit Sollier C., Dillinger J.G., Berge N., Brouland J.P., Henry P., Drouet L.
ISSN
1969-6213 (Electronic)
ISSN-L
1774-024X
Publication state
Published
Issued date
05/04/2019
Peer-reviewed
Oui
Volume
14
Number
18
Pages
e1843-e1851
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
We sought to develop a reproducible animal model for acute myocardial infarction (AMI) in adult atherosclerosis-prone pigs.
A coil was placed in the right coronary artery or the left anterior descending artery in 26 downsized spontaneously hypercholesterolaemic pigs and left untreated until thrombotic occlusion. Then, we crossed the thrombotic occlusion with a guidewire, followed by predilatation, thrombus visualisation with optical coherence tomography (OCT) imaging and, finally, deployment of a stent and repeated OCT. After revascularisation, we calculated the index of microcirculatory resistance (IMR). After a feasibility phase (six animals), acute thrombotic occlusion was achieved in all 20 pigs. Eighteen animals were successfully revascularised and survived until sacrifice. Thrombus formation was confirmed by OCT, measurement of thrombin-antithrombin complexes and pathology examination. Myocardial necrosis was confirmed by troponin T elevation, myocardial staining and pathology examination. Distal thrombotic embolisation and microvascular obstruction were supported by increased IMR and pathology examination.
A porcine model of thrombotic occlusion AMI in miniaturised adult spontaneously atherosclerosis-prone pigs is feasible by percutaneous intracoronary placement of a coil. The reperfusion by angioplasty completed this model which mirrors human pathological conditions with myocardial infarction, necrosis and distal embolisation.
Pubmed
Web of science
Create date
28/05/2019 10:18
Last modification date
20/08/2019 13:52
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