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A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
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Publication types: Journal Article
B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.
Amino Acid Sequence, Antigens, CD40, Antigens, Differentiation, B-Lymphocyte/genetics, B-Lymphocytes/immunology, Base Sequence, Biological Factors/pharmacology, Carcinoma/genetics, Carcinoma/immunology, Cytokines, Gene Expression Regulation, HLA-DR Antigens/genetics, Humans, Lymphocyte Activation, Molecular Sequence Data, Mutation, Nerve Growth Factors/metabolism, Receptors, Cell Surface/genetics, Receptors, Nerve Growth Factor, Sequence Homology, Nucleic Acid
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