The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells

Détails

ID Serval
serval:BIB_46CD5932F654
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells
Périodique
EMBO Journal
Auteur(s)
Stamenkovic  I., Aruffo  A., Amiot  M., Seed  B.
ISSN
0261-4189 (Print)
Statut éditorial
Publié
Date de publication
1991
Volume
10
Numéro
2
Pages
343-348
Notes
PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't
Résumé
CD44 is a polymorphic integral membrane protein which recognizes hyaluronate and whose proposed roles encompass lymphocyte activation, matrix adhesion and the attachment of lymphocytes to lymph node high endothelial venules (HEVs). Immunochemical and RNA blot data have supported the existence of two forms of CD44: a hematopoietic form expressed by cells of mesodermal origin (and by some carcinoma cell lines) and an epithelial form weakly expressed by normal epithelium but highly expressed by carcinomas. This report describes the isolation of a cDNA encoding a distinct CD44 polypeptide expressed by epithelial cells. Re-expression of each form of CD44 in a B cell line allowed cells transfected with the hematopoietic but not the epithelial form to bind to viable rat lymph node HEV cells in primary culture
Mots-clé
Amino Acid Sequence/Animals/Base Sequence/Cell Adhesion/Cell Line/Cells,Cultured/Cloning,Molecular/Colonic Neoplasms/Dna/genetics/Epithelium/immunology/Flow Cytometry/Gene Library/Hematopoietic Stem Cells/Humans/Hyaluronic Acid/metabolism/Lymph Nodes/Molecular Sequence Data/Rats/Receptors,Lymphocyte Homing/Restriction Mapping/Transfection/Research
Pubmed
Web of science
Création de la notice
29/01/2008 19:34
Dernière modification de la notice
03/03/2018 16:48
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