Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors.

Détails

ID Serval
serval:BIB_4639F3EF49BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Positron emission tomography for the early postsurgical evaluation of pediatric brain tumors.
Périodique
Child's Nervous System
Auteur(s)
Pirotte B., Levivier M., Morelli D., Van Bogaert P., Detemmerman D., David P., Baleriaux D., Brotchi J., Goldman S.
ISSN
0256-7040 (Print)
ISSN-L
0256-7040
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
21
Numéro
4
Pages
294-300
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
OBJECT: The object was to study the value of postoperative positron emission tomography (PET) to assess the extension of brain tumor resection.
METHODS: Twenty children operated on for total resection of a glial tumor (18 low-grade, 2 anaplastic) presented a signal on postoperative magnetic resonance (MR) images raising the question of a possible tumor residue. PET was performed early ((18)F-Fluoro-deoxyglucose in 1, (11)C-methionine in 16, both in 3) to further characterize the nature of the abnormal MR signal in order to consider second-look surgery. An increased tracer uptake found in 14 children led to reoperation on 11 of them, confirming the tumor histologically. No (11)C-methionine uptake led to a conservative attitude in 6 children in whom MR imaging follow-up showed no tumor progression.
CONCLUSIONS: The early postoperative PET, especially with (11)C-methionine, appears to be a valid basis for complementary therapeutic decisions, especially second-look surgery, in glial tumors for which a radical resection is a key factor for prognosis.
Mots-clé
Adolescent, Brain Neoplasms/pathology, Brain Neoplasms/radionuclide imaging, Child, Child, Preschool, Female, Fluorodeoxyglucose F18/diagnostic use, Fluorodeoxyglucose F18/pharmacokinetics, Humans, Image Processing, Computer-Assisted/methods, Male, Methionine/diagnostic use, Methionine/pharmacokinetics, Positron-Emission Tomography, Retrospective Studies
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
03/03/2018 16:47
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