Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.

Details

Serval ID
serval:BIB_45F52495AEE6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.
Journal
Atherosclerosis
Author(s)
Marangoni A., Fiorino E., Gilardi F., Aldini R., Scotti E., Nardini P., Foschi C., Donati M., Montagnani M., Cevenini M., Franco P., Roda A., Crestani M., Cevenini R.
ISSN
1879-1484 (Electronic)
ISSN-L
0021-9150
Publication state
Published
Issued date
08/2015
Peer-reviewed
Oui
Volume
241
Number
2
Pages
471-479
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Chlamydia pneumoniae has been linked to atherosclerosis, strictly associated with hyperlipidemia. The liver plays a central role in the regulation of lipid metabolism. Since in animal models C. pneumoniae can be found at hepatic level, this study aims to elucidate whether C. pneumoniae infection accelerates atherosclerosis by affecting lipid metabolism.
Thirty Balb/c mice were challenged intra-peritoneally with C. pneumoniae elementary bodies and thirty with Chlamydia trachomatis, serovar D. Thirty mice were injected with sucrose-phosphate-glutamate buffer, as negative controls. Seven days after infection, liver samples were examined both for presence of chlamydia and expression of genes involved in inflammation and lipid metabolism.
C. pneumoniae was isolated from 26 liver homogenates, whereas C. trachomatis was never re-cultivated (P < 0.001). C. pneumoniae infected mice showed significantly increased serum cholesterol and triglycerides levels compared both with negative controls (P < 0.001 and P = 0.0197, respectively) and C. trachomatis infected mice (P < 0.001). Liver bile acids were significantly reduced in C. pneumoniae compared to controls and C. trachomatis infected mice. In C. pneumoniae infected livers, cholesterol 7α-hydroxylase (Cyp7a1) and low-density lipoprotein receptor (Ldlr) mRNA levels were reduced, while inducible degrader of the low-density lipoprotein receptor (Idol) expression was increased. Hypertriglyceridemia was associated to reduced expression of hepatic carnitine palmitoyltransferase-1a (Cpt1a) and medium chain acyl-Coenzyme A dehydrogenase (Acadm). Pro-inflammatory cytokines gene expression was increased compared to negative controls. Conversely, in C. trachomatis infected animals, normal serum lipid levels were associated with elevated pro-inflammatory cytokines gene expression, linked to only a mild disturbance of lipid regulatory genes.
Our results indicate that C. pneumoniae mouse liver infection induces dyslipidemic effects with significant modifications of genes involved in lipid metabolism.
Keywords
Acyl-CoA Dehydrogenase/metabolism, Animals, Atherosclerosis/complications, Atherosclerosis/microbiology, Bile Acids and Salts/metabolism, Carnitine O-Palmitoyltransferase/metabolism, Chlamydia Infections/complications, Chlamydia Infections/microbiology, Chlamydia trachomatis, Chlamydophila pneumoniae, Cholesterol/metabolism, Cytokines/metabolism, Gene Expression Regulation, Glutamic Acid/chemistry, Inflammation, Infusions, Parenteral, Lipid Metabolism, Lipids/blood, Liver/metabolism, Liver/microbiology, Liver Failure, Acute/microbiology, Male, Mice, Mice, Inbred BALB C, Phosphates/chemistry, Sucrose/chemistry, Triglycerides/metabolism, Atherosclerosis, C. pneumoniae, Carnitine palmitoyltransferase, Cholesterol, Cholesterol 7α-hydroxylase, Inducible nitric oxide synthase, Interleukin-1β, Low-density lipoprotein receptor, Low-density lipoprotein receptor degrader, Medium chain acyl-CoA dehydrogenase
Pubmed
Web of science
Create date
21/03/2019 11:29
Last modification date
17/10/2023 13:16
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