Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.

Détails

ID Serval
serval:BIB_45E4EA3E2F74
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.
Périodique
Molecular Pharmacology
Auteur(s)
Mennini T., Poggesi E., Cotecchia S., De Blasi A., Samanin R.
ISSN
0026-895X (Print)
ISSN-L
0026-895X
Statut éditorial
Publié
Date de publication
1981
Volume
20
Numéro
2
Pages
237-239
Langue
anglais
Résumé
Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [3H]dihydroalprenolol, 2,2,6-[3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central
Mots-clé
Animals, Brain/metabolism, Carrier Proteins/metabolism, Catecholamine Plasma Membrane Transport Proteins, Catecholamines/metabolism, Dihydroalprenolol/pharmacology, Dioxanes/metabolism, Humans, Kinetics, Male, Membrane Transport Proteins, Membranes/metabolism, Morphine Dependence/metabolism, Rats, Receptors, Serotonin/metabolism, Spiperone/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 12:05
Dernière modification de la notice
03/03/2018 16:46
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