Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.
Details
Serval ID
serval:BIB_45E4EA3E2F74
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.
Journal
Molecular Pharmacology
ISSN
0026-895X (Print)
ISSN-L
0026-895X
Publication state
Published
Issued date
1981
Volume
20
Number
2
Pages
237-239
Language
english
Abstract
Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [3H]dihydroalprenolol, 2,2,6-[3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central
Keywords
Animals, Brain/metabolism, Carrier Proteins/metabolism, Catecholamine Plasma Membrane Transport Proteins, Catecholamines/metabolism, Dihydroalprenolol/pharmacology, Dioxanes/metabolism, Humans, Kinetics, Male, Membrane Transport Proteins, Membranes/metabolism, Morphine Dependence/metabolism, Rats, Receptors, Serotonin/metabolism, Spiperone/metabolism
Pubmed
Web of science
Create date
24/01/2008 12:05
Last modification date
20/08/2019 14:51
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