Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia.

Détails

ID Serval
serval:BIB_45DF8753C8C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia.
Périodique
Chest
Auteur(s)
Boeck L., Graf R., Eggimann P., Pargger H., Raptis D.A., Smyrnios N., Thakkar N., Siegemund M., Rakic J., Tamm M., Stolz D.
ISSN
1931-3543 (Electronic)
ISSN-L
0012-3692
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
140
Numéro
4
Pages
925-932
Langue
anglais
Résumé
Background: Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of nosocomial pneumonia remain a global burden. Currently, physicians rely on their experience to discriminate patients with good and poor outcome. However, standardized prognostic measures might guide medical decisions in the future. Pancreatic stone protein (PSP)/regenerating protein (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill patients is unknown. The aim of this pilot study was to evaluate PSP/reg in VAP.Methods: One hundred one patients with clinically diagnosed VAP were assessed. PSP/reg was retrospectively analyzed using deep-frozen serum samples from VAP onset up to day 7. The main end point was death within 28 days after VAP onset.Results: Serum PSP/reg was associated with the sequential organ failure assessment score from VAP onset (Spearman rank correlation coefficient 0.49 P < .001) up to day 7. PSP/reg levels at VAP onset were elevated in nonsurvivors (n = 20) as compared with survivors (117.0 ng/mL [36.1-295.3] vs 36.3 ng/mL [21.0-124.0] P = .011). The areas under the receiver operating characteristic curves of PSP/reg to predict mortality/survival were 0.69 at VAP onset and 0.76 at day 7. Two PSP/reg cutoffs potentially allow for identification of individuals with a particularly good and poor outcome. Whereas PSP/reg levels below 24 ng/mL at YAP onset were associated with a good chance of survival, levels above 177 ng/mL at day 7 were present in patients with a very poor outcome.Conclusions: Serum PSP/reg is a biomarker related to organ failure and outcome in patients with VAP.
Pubmed
Web of science
Création de la notice
17/11/2011 10:41
Dernière modification de la notice
03/03/2018 16:46
Données d'usage